Evaluation of Antioxidant Activities of Ampelopsin and Its Protective Effect in Lipopolysaccharide-Induced Oxidative Stress Piglets
نویسندگان
چکیده
The aim of this study was to investigate the antioxidant potential of ampelopsin (APS) by using various methods in vitro, as well as to determine effects of APS on LPS-induced oxidative stress in piglets. The results showed that APS exhibited excellent free radical scavenging by DPPH, ABTS, O2•-, H2O2 and ferric reducing antioxidant power. Ampelopsin also protected pig erythrocytes against AAPH-induced apoptosis and hemolysis, decreased total superoxide dismutase activity, and increased lipid peroxidation. Furthermore the results demonstrated that APS enhanced the total antioxidant capacity and decreased the malondialdehyde and protein carbonyl contents in LPS-treated piglets. The results of the present investigation suggest that APS possesses a strong antioxidant activity and alleviates LPS-induced oxidative stress, possibly due to its ability to prevent reactive oxygen species.
منابع مشابه
Changes of stress oxidative enzymes in rat mammary tissue, blood and milk after experimental mastitis induced by E. coli lipopolysaccharide
The present study investigated the effects of E. coli lipopolysaccharide (LPS) induced mastitis model in rat on the activity of antioxidant enzyme systems. To achieve this purpose, E. coli LPS were infused into the mammary gland of 12 rats 72 hr postpartum and compared with 12 rats in control group infused intramammary placebo sterile pyrogene – free, physiological saline. The...
متن کاملEvaluation of the protective effect of Satureja khozestanica essential oil on in vitro fertilization potential and embryo development in oxidative stress induced by Nonylphenol
Background & aim: Nonylphenol (NP) has been known as an immunosuppressant agent, and reported to induce oxidative stress, to impact gonadal cells nucleus and to reduce the fertilizing potential. Therefore, present study was aimed to evaluate the protective effect of Satureja Khuzestanica, as a potential antioxidant, on in vitro fertilized embryos development following exposure to NP. Methods: ...
متن کاملProtective Effects of Pelargonium graveolens Essential Oil on methomyl-Induced Oxidative Stress and Spatial Working Memory Impairment in Association with Histopathological Changes in the Hippocampus of Male Wistar Rats
Introduction: Methomyl (MET) is a carbamate insecticide, used in agriculture and public health to eliminate harmful insects. Besides its advantages in agriculture, it causes neurotoxic effects. The aim of this study was to evaluate the effect of MET on Spatial Working Memory (SWM), oxidative stress parameters, and histopathological changes in the hippocampus, as well as the possible protective...
متن کاملAssessment of Streptococcus Salivarius ssp Thermophilus Antioxidant Efficiency and its Role in Reducing Paracetamol Hepatotoxicity
Background: Probiotics have attracted a great attention aiming to develop natural non-toxic antioxidants, because of their role in decreasing the risk of reactive oxygen species (ROS) accumulation. Objectives: The purpose of this study was to assess the antioxidant activity of a probiotic Streptococcus salivarius ssp thermophillus (St.sa) and to evaluate its protective effect against the ...
متن کاملProtective effect of ginger on diazinon-induced brain toxicity
Background and objectives: Diazinon (DZN), an organophosphate insecticide, is widely used in agriculture. One of its deleterious effects is on neural systems. Diazinon with acetylcholinesterase activity and lipid peroxidation induces brain toxicity . Ginger, as a medicinal plant, has antioxidant and anti-imflammatory properties. The aim of present study was to evaluate...
متن کامل